Biagianti S, Corsin J
Arch Anat Microsc Morphol Exp. 1982;71(1):41-9.
The importance of cell-matrix interactions during terminal chondrocyte differentiation is to-day accepted by all authors. Na-hyaluronate micro-injections induce an increase of perichondral thickness and maintain mesenchymal aspect in chondrocyte. Cytoplasmic organelles show anomalies which may be bound to disturbance in cellular metabolism. An important decrease of matrix-constituents is observed, a fact showing that high hyaluronate concentration interferes with chondroitin-sulfate synthesis or secretion and collagen organization.
终末软骨细胞分化过程中细胞与基质相互作用的重要性如今已被所有作者所接受。注射透明质酸钠可使软骨膜厚度增加，并使软骨细胞保持间充质状态。细胞质细胞器出现异常，这可能与细胞代谢紊乱有关。观察到基质成分显著减少，这一事实表明高浓度透明质酸会干扰硫酸软骨素的合成或分泌以及胶原蛋白的组织。
