Halberg P, Ullman S, Jørgensen F
Arch Dermatol. 1982 Aug;118(8):572-6.
One hundred twenty-seven biopsy specimens from clinically normal light-protected skin of 88 patients with active and inactive lupus erythematosus (LE) were examined for deposits of IgG, IgM, IgA, and C3 at the dermal-epidermal junction (DEJ). Deposits were found in 91% of those with active disease and in 33% of those with inactive disease. The finding of such deposits reflected active disease just as did a decrease in serum C3 and C4 levels, elevated anti-double-stranded DNA, the presence of LE cells, lymphopenia, and an elevation of the ESR. The presence or absence of deposits in repeated biopsy specimens indicated changing disease activity, as estimated clinically, just as did changes in the other variables mentioned. Neither immunoreactants in skin nor any other laboratory abnormality reflected renal disease or other type of organ involvement. Deposits of IgG were not more commonly found in patients with renal disease.
对88例活动期和非活动期红斑狼疮（LE）患者临床正常、光照防护皮肤的127份活检标本进行检测，以观察真皮表皮交界处（DEJ）IgG、IgM、IgA和C3的沉积情况。活动期患者中91%发现有沉积物，非活动期患者中33%发现有沉积物。此类沉积物的发现反映了疾病的活动情况，血清C3和C4水平降低、抗双链DNA升高、LE细胞的存在、淋巴细胞减少以及血沉升高也反映了疾病的活动情况。重复活检标本中沉积物的有无表明疾病活动情况在变化，这与临床估计的情况一致，其他提及的变量变化也是如此。皮肤中的免疫反应物或任何其他实验室异常均未反映出肾脏疾病或其他类型的器官受累情况。肾病患者中IgG沉积物并非更常见。
