Ostrander C R, Cohen R S, Hopper A O, Cowan B E, Stevens G B, Stevenson D K
J Lab Clin Med. 1982 Nov;100(5):745-55.
Paired determinations of COHb and VeCO were performed on 30 term infants (38 to 42 weeks' gestation) and 26 preterm infants (28 to 37 weeks' gestation) during the first week of life. All subjects were breathing room air at the time of the study. Values of COHb were corrected for RAco by linear regression of COHb (percent saturation) vs RAco (ppm). Regression coefficients for term and preterm infants with no history of pulmonary impairment were nearly identical (COHb = 0.175 RAco + 0.45, r = 0.77, n = 25 for term infants; COHb = 0.168 RAco + 0.51, r = 0.82, n = 9 for preterm infants) and agreed well with theoretical values. For the group of term infants, linear regression of Veco (microliter/kg/hr) vs. COHbc, where COHbc = COHb - 0.17 RAco, resulted in VEco = 23.4 COHbc + 4.02, r = 0.75, n = 30. The corresponding relationship for preterm infants with no history of pulmonary impairment was VEco = 24.7 COHbc + 3.85, r = 0.61, n = 13. For a subpopulation of preterm infants with a history of pulmonary dysfunction, the correlation decreased significantly, with VEco = 4.34 COHbc + 17.6, r = 0.097, n = 11. These results demonstrate that (1) COHbc is a reasonable index of VEco and consequently of the heme catabolic rate in both term and preterm infants with no clinical history of pulmonary dysfunction and (2) inference of VEco from COHbc may be misleading in certain cases without a consideration of the factors relating these two variables.
在出生后第一周，对30名足月儿（妊娠38至42周）和26名早产儿（妊娠28至37周）进行了碳氧血红蛋白（COHb）和一氧化碳排出量（VeCO）的配对测定。研究时所有受试者均呼吸室内空气。通过将COHb（饱和度百分比）与呼吸空气一氧化碳（RAco，ppm）进行线性回归，对COHb值进行了RAco校正。无肺部损害病史的足月儿和早产儿的回归系数几乎相同（足月儿：COHb = 0.175RAco + 0.45，r = 0.77，n = 25；早产儿：COHb = 0.168RAco + 0.51，r = 0.82，n = 9），且与理论值吻合良好。对于足月儿组，一氧化碳排出量（Veco，微升/千克/小时）与校正碳氧血红蛋白（COHbc，其中COHbc = COHb - 0.17RAco）的线性回归结果为：VEco = 23.4COHbc + 4.02，r = 0.75，n = 30。无肺部损害病史的早产儿的相应关系为：VEco = 24.7COHbc + 3.85，r = 0.61，n = 13。对于有肺部功能障碍病史的早产儿亚组，相关性显著降低，为VEco = 4.34COHbc + 17.6，r = 0.097，n = 11。这些结果表明：（1）在无肺部功能障碍临床病史的足月儿和早产儿中，COHbc是VEco以及血红素分解代谢率的合理指标；（2）在某些情况下，如果不考虑与这两个变量相关的因素，从COHbc推断VEco可能会产生误导。
