肾上腺髓质通过中枢作用在吗啡诱导的体温升高中的作用。
Role of adrenal medulla in morphine-induced hyperthermia through central action.
作者信息
Wallenstein M C
出版信息
Br J Pharmacol. 1982 Aug;76(4):565-8. doi: 10.1111/j.1476-5381.1982.tb09255.x.
Abstract
The role of the adrenal glands, in morphine-induced hyperthermia was studied in normal, chemically-sympathectomized, adrenalectomized, adrenal-demedullated or splanchnicotomized rats. 2. In restrained female rats, 5 mg/kg morphine produced hyperthermia whereas 20 mg/kg and 40 mg/kg produced hyperthermia. 3. After adrenalectomy, 5 mg/kg morphine did not produce hyperthermia. 4. After adrenal-demedullation or adrenal-denervation (splanchnicotomy), 5 mg/kg morphine did not produce hyperthermia. 5. The results suggest that, in the rat, the adrenal medulla plays an important role in morphine-induced hyperthermia, and that morphine acts centrally to stimulate the medulla.
摘要
在正常、化学性交感神经切除、肾上腺切除、肾上腺髓质剥除或内脏神经切断的大鼠中，研究了肾上腺在吗啡诱导的体温过高中的作用。2. 在受限制的雌性大鼠中，5毫克/千克吗啡可导致体温过高，而20毫克/千克和40毫克/千克也会导致体温过高。3. 肾上腺切除后，5毫克/千克吗啡不会导致体温过高。4. 肾上腺髓质剥除或肾上腺去神经支配（内脏神经切断）后，5毫克/千克吗啡不会导致体温过高。5. 结果表明，在大鼠中，肾上腺髓质在吗啡诱导的体温过高中起重要作用，且吗啡通过作用于中枢来刺激髓质。
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