Griffiths I R, Kelly P A, Carmichael S, McCulloch M, Waterston M
Brain Res. 1981 Oct 19;222(2):447-51. doi: 10.1016/0006-8993(81)91053-2.
A reduction in local glucose utilization occurs in the superficial layer of the superior colliculus of rats following exposure to 0.5% 2,5-hexanedione in drinking water for 3 weeks. Axonal pathology, with increased neurofilaments and swelling, is seen at about 5 weeks in the distal portions of the optic pathways to the superior colliculus. These lesions in the optic system occur earlier and are more marked than those in the peripheral nerves and dorsal columns. The results suggest that the functional abnormality, as implied by the decreased glucose utilization, precedes the morphological changes in hexacarbon neuropathy.
给大鼠饮用含0.5% 2,5 -己二酮的水3周后，其 superior colliculus（上丘）表层的局部葡萄糖利用率降低。在通向superior colliculus的视通路远端部分，约5周时可见轴突病变，伴有神经丝增加和肿胀。视系统中的这些病变比周围神经和背柱中的病变出现得更早且更明显。结果表明，如葡萄糖利用率降低所暗示的功能异常在己二酮神经病变的形态学变化之前出现。
