Hostetter M W, Dawson C A, Moore V L, Ju-Ger C K
Int Arch Allergy Appl Immunol. 1982;69(2):179-87. doi: 10.1159/000233168.
Isolated perfused rabbit lungs were insufflated with 125I-labeled bovine serum albumin (125I-BSA) and the accumulation of radioactive BSA and its breakdown products was measured in the blood. The addition of anti-BSA serum to the blood caused a 4- to 6-fold reduction in the amount of 125I-BSA which appeared in the blood following the insufflation. To determine whether this reduction was the result of inhibition of absorption or the reuptake of 125I-BSA antigen-antibody complexes formed in the blood, we infused the 125I-BSA into the anti-BSA containing blood perfusing the lungs. Virtually none of the radioactivity was taken up by the lungs, indicating that the reduced blood levels following insufflation were the result of reduced absorption through the lung resulting from antigen-antibody interaction within the alveolocapillary membrane or the bronchoalveolar secretions.
将125I标记的牛血清白蛋白（125I-BSA）注入离体灌注的兔肺中，并测定血液中放射性BSA及其分解产物的蓄积量。向血液中添加抗BSA血清会使吹入后血液中出现的125I-BSA量减少4至6倍。为了确定这种减少是由于吸收抑制还是血液中形成的125I-BSA抗原-抗体复合物的再摄取所致，我们将125I-BSA注入灌注肺的含抗BSA血液中。肺几乎没有摄取任何放射性，这表明吹入后血液水平降低是由于肺泡毛细血管膜或支气管肺泡分泌物内的抗原-抗体相互作用导致通过肺的吸收减少所致。
