Jacobs E R, Soulsby M E, Bone R C, Wilson F J, Hiller F C
J Clin Invest. 1982 Sep;70(3):536-41. doi: 10.1172/jci110645.
The participation of prostaglandins in the physiologic alterations of endotoxin shock has been well established with the aid of prostaglandin synthetase inhibitors. Our study was designed to investigate the potential of ibuprofen, a highly specific cyclooxygenase inhibitor, to reverse the hemodynamic and acid base abnormalities of canine endotoxin shock. Mean blood pressure fell to 49.8 +/- 6.6 mm Hg in dogs given endotoxin by 5 min after injection, and remained below 83 mm Hg for the duration of the 120-min observation period. In animals given endotoxin followed by ibuprofen, a similar initial drop of systemic blood pressure was seen, but it subsequently recovered to 150.2 +/- 4.1 mm Hg by 120 min (P less than 0.001). Cardiac index increased in animals given ibuprofen (2.3 +/- 0.28 liter/m2 per min) compared with animals given endotoxin alone (1.0 +/- 0.09 liter/m2 per min) by termination of the experiment. The arterial pH dropped in endotoxin treated animals to 7.18 +/- 0.03 by 120 min. Ibuprofen prevented the acidosis, the final pH in ibuprofen and endotoxin treated animals measuring 7.36 +/- 0.01. We conclude that ibuprofen protects against the hypotension, acidosis, and depression of cardiac index of canine endotoxin shock.
借助前列腺素合成酶抑制剂，前列腺素参与内毒素休克的生理改变已得到充分证实。我们的研究旨在探究布洛芬（一种高度特异性的环氧化酶抑制剂）逆转犬内毒素休克血流动力学和酸碱异常的潜力。注射内毒素后5分钟，给予内毒素的犬平均血压降至49.8±6.6毫米汞柱，并在120分钟观察期内持续低于83毫米汞柱。在给予内毒素后再给予布洛芬的动物中，观察到类似的全身性血压初始下降，但随后在120分钟时恢复至150.2±4.1毫米汞柱（P＜0.001）。到实验结束时，给予布洛芬的动物心脏指数增加（2.3±0.28升/平方米每分钟），而单独给予内毒素的动物心脏指数为（1.0±0.09升/平方米每分钟）。给予内毒素的动物动脉pH值在120分钟时降至7.18±0.03。布洛芬可预防酸中毒，给予布洛芬和内毒素的动物最终pH值为7.36±0.01。我们得出结论，布洛芬可预防犬内毒素休克的低血压、酸中毒和心脏指数降低。
