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糖尿病和非糖尿病中国仓鼠的主要血浆糖蛋白。

Major plasma glycoproteins of diabetic and nondiabetic Chinese hamsters.

作者信息

Copeland E J, Ginsberg L C

出版信息

J Hered. 1982 Jul-Aug;73(4):311-3. doi: 10.1093/oxfordjournals.jhered.a109656.

DOI:10.1093/oxfordjournals.jhered.a109656
PMID:7108192
Abstract

Differences were noted in the plasma glycoprotein electrophoretic profile of diabetic versus nondiabetic chinese hamster. The variant plasma proteins were identified by chromatographic and electrophoretic procedures as transferrin (Tf) and alpha 2 macroglobulin (alpha 2M). The transferrin variants were line dependent and not altered in streptozotesin induced diabetics. Alpha 2M patterns were changed to that of the diabetics after streptozotesin treatment, and therefore are metabolic variants.

摘要

在糖尿病与非糖尿病中国仓鼠的血浆糖蛋白电泳图谱中发现了差异。通过色谱和电泳方法鉴定出变异的血浆蛋白为转铁蛋白(Tf)和α2巨球蛋白(α2M)。转铁蛋白变异体与品系有关,在链脲佐菌素诱导的糖尿病仓鼠中未发生改变。链脲佐菌素治疗后,α2M图谱变为糖尿病仓鼠的图谱,因此是代谢变异体。

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