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新城疫病毒糖蛋白的脂肪酸修饰

Fatty acid modification of Newcastle disease virus glycoproteins.

作者信息

Chatis P A, Morrison T G

出版信息

J Virol. 1982 Jul;43(1):342-7. doi: 10.1128/JVI.43.1.342-347.1982.

DOI:10.1128/JVI.43.1.342-347.1982
PMID:7109029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256127/
Abstract

The fatty acid acylation of Newcastle disease virus hemagglutininin-neuraminidase and fusion glycoproteins was assayed. [3H]palmitate label was associated with cytoplasmic fusion proteins (F0 and F1) and virion-associated F1. In contrast, there was no detectable [3H]palmitate label associated with the hemagglutin-neuraminidase protein in Newcastle disease virus-infected Chinese hamster ovary cells or chicken embryo cells or in virions released from these cells. Thus, fatty acid modification may not be important for the maturation of some glycoproteins.

摘要

对新城疫病毒血凝素 - 神经氨酸酶和融合糖蛋白的脂肪酸酰化作用进行了测定。[3H]棕榈酸盐标记与细胞质融合蛋白(F0和F1)以及病毒体相关的F1相关。相比之下,在新城疫病毒感染的中国仓鼠卵巢细胞或鸡胚细胞中,或从这些细胞释放的病毒体中,未检测到与血凝素 - 神经氨酸酶蛋白相关的[3H]棕榈酸盐标记。因此,脂肪酸修饰可能对某些糖蛋白的成熟并不重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/46a4cc9f70e5/jvirol00154-0357-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/01399147e55f/jvirol00154-0355-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/fa693b43a440/jvirol00154-0356-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/46a4cc9f70e5/jvirol00154-0357-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/01399147e55f/jvirol00154-0355-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/fa693b43a440/jvirol00154-0356-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/256127/46a4cc9f70e5/jvirol00154-0357-a.jpg

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本文引用的文献

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Synthesis, stability, and cleavage of Newcastle disease virus glycoproteins in the absence of glycosylation.新城疫病毒糖蛋白在无糖基化情况下的合成、稳定性及裂解
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Transcriptional map for Newcastle disease virus.新城疫病毒转录图谱。
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Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus G and M proteins determined from cDNA clones containing the complete coding regions.从包含完整编码区的cDNA克隆中确定的编码水疱性口炎病毒G蛋白和M蛋白的mRNA的核苷酸序列。
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