Ochiai T, Ishida R
Jpn J Pharmacol. 1982 Jun;32(3):427-38. doi: 10.1254/jjp.32.427.
Effects of afloqualone on mono- (MSR) and poly-synaptic reflex (PSR) potentials and alpha- and gamma-rigidities were studied in experimental animals. Afloqualone dose dependently inhibited both MSR and PSR potentials in spinalized cats though afloqualone had no inhibitory effect on the patellar reflex in cats as reported in the previous paper. Afloqualone, like tolperisone, more selectively inhibited the PSR potential than MSR potential, whereas baclofen inhibited them in reverse order. However, the selectivity towards the PSR potential was higher with afloqualone than with tolperisone. In rats and cats, afloqualone dose dependently relaxed both alpha- and gamma-rigidity when administered p.o. as well as i.v. Its 50% inhibitory dose for alpha-rigidity was 1.5-2 times larger than that for gamma-rigidity. Tolperisone also relaxed both rigidities in i.v. administration, but had little effect when given p.o. Only mephenesin relaxed the post-ischaemic spinal rigidity in cats. These results suggest that afloqualone, like other well known centrally acting muscle relaxants except for baclofen, more strongly inhibits the polysynaptic pathway than the mono-synaptic pathway of the spinal cord as well as more strongly the gamma-system than the alpha-system.
在实验动物中研究了阿夫喹酮对单突触反射（MSR）和多突触反射（PSR）电位以及α和γ僵直的影响。阿夫喹酮剂量依赖性地抑制脊髓麻醉猫的MSR和PSR电位，尽管如前文报道，阿夫喹酮对猫的髌反射没有抑制作用。与托哌酮一样，阿夫喹酮对PSR电位的抑制作用比MSR电位更具选择性，而巴氯芬则以相反的顺序抑制它们。然而，阿夫喹酮对PSR电位的选择性高于托哌酮。在大鼠和猫中，口服和静脉注射阿夫喹酮均剂量依赖性地减轻α和γ僵直。其对α僵直的50%抑制剂量比对γ僵直的大1.5 - 2倍。托哌酮静脉注射时也能减轻两种僵直，但口服时作用很小。只有美芬新能减轻猫缺血后脊髓僵直。这些结果表明，与除巴氯芬外的其他知名中枢性肌肉松弛剂一样，阿夫喹酮对脊髓多突触通路的抑制作用比对单突触通路更强，对γ系统的抑制作用比对α系统更强。
