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新西兰白兔遗传性青光眼的临床与病理研究

A clinical and pathological study of inherited glaucoma in New Zealand white rabbits.

作者信息

Tesluk G C, Peiffer R L, Brown D

出版信息

Lab Anim. 1982 Jul;16(3):234-9. doi: 10.1258/002367782780891679.

DOI:10.1258/002367782780891679
PMID:7109527
Abstract

The eyes of 7 rabbits with clinical megaloglobus, selected from a large colony, were studied with slit-lamp microscopy, gonioscopy, indirect ophthalmoscopy and tonometry. Selected light and scanning electron microscopy was also performed. There were 11 glaucomatous eyes among the 7 rabbits: gonioscopy demonstrated open iridocorneal angles with absence of pectinate fibres. Incomplete cleavage of the iridocorneal angles in glaucomatous eyes was noted histologically. Because of the similarity of the iridocorneal angles of glaucomatous rabbit eyes with those of human eyes with congenital glaucoma, these rabbits may serve as an experimental model in the understanding and management of certain types of human glaucoma.

摘要

从一个大群体中挑选出7只患有临床性眼球增大症的兔子,对其眼睛进行了裂隙灯显微镜检查、前房角镜检查、间接检眼镜检查和眼压测量。还进行了选择性光镜和扫描电子显微镜检查。这7只兔子中有11只眼睛患有青光眼:前房角镜检查显示虹膜角膜角开放,梳状纤维缺失。组织学检查发现青光眼性眼睛的虹膜角膜角有不完全裂开。由于青光眼性兔眼的虹膜角膜角与先天性青光眼患者的虹膜角膜角相似,这些兔子可作为一种实验模型,用于理解和治疗某些类型的人类青光眼。

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1
A clinical and pathological study of inherited glaucoma in New Zealand white rabbits.新西兰白兔遗传性青光眼的临床与病理研究
Lab Anim. 1982 Jul;16(3):234-9. doi: 10.1258/002367782780891679.
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Clinical manifestations of inherited glaucoma in the beagle.比格犬遗传性青光眼的临床表现。
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Anterior segment alterations and comparative aqueous humor proteomics in the buphthalmic rabbit (an American Ophthalmological Society thesis).牛眼兔眼前节改变及房水蛋白质组学比较(美国眼科学会论文)
Trans Am Ophthalmol Soc. 2011 Dec;109:66-114.