比格犬遗传性青光眼的临床表现。

Clinical manifestations of inherited glaucoma in the beagle.

作者信息

Gelatt K N, Peiffer R L, Gwin R M, Gum G G, Williams L W

出版信息

Invest Ophthalmol Vis Sci. 1977 Dec;16(12):1135-42.

Abstract

Inherited glaucoma was exhibited in 55 beagles. The glaucomatous process was divided into early (6 to 12 months of age), moderate (13 to 30 months of age), and advanced (31 months of age). In early glaucoma the tridocorneal angles, as judged by gonioscopy, were open and without anomalies, intraocular pressure was elevated, and the tonographic facility of aqueous outflow was decreased. With moderate glaucoma, the tridocorneal angles were typically open; intraocular pressure was elevated, facility of aqueous outflow was decreased; and variable optic disc cupping and focal disinsertion of the zonules from the lens were seen. Advanced glaucoma exhibited narrow to closed tridocorneal angles, decreased facility of aqueous outflow, elevated intraocular pressure, lens dislocation, optic disc atrophy, and finally phthisis bulbi. The beagle in the early and moderate stages of glaucoma, before angle closure and lens dislocation, is an animal model for studies in open-angle glaucoma.

摘要

55只比格犬表现出遗传性青光眼。青光眼病程分为早期（6至12月龄）、中期（13至30月龄）和晚期（31月龄及以上）。在早期青光眼中，通过前房角镜检查判断，前房角开放且无异常，眼压升高，房水流出的眼压描记值降低。在中度青光眼中，前房角通常开放；眼压升高，房水流出值降低；可见视盘杯状凹陷以及晶状体悬韧带的局部离断。晚期青光眼表现为前房角狭窄至关闭、房水流出值降低、眼压升高、晶状体脱位、视盘萎缩，最终眼球萎缩。处于青光眼早期和中期阶段、在房角关闭和晶状体脱位之前的比格犬，是开角型青光眼研究的动物模型。