Kashiwagi Emi, Masuno Koichi, Fujisawa Kae, Matsushima Shuuichi, Torii Mikinori, Takasu Nobuo
Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
J Toxicol Pathol. 2012 Mar;25(1):51-3. doi: 10.1293/tox.25.51.
Goniodysgenesis, malformation of the filtration angle, was observed in a New Zealand white rabbit supplied with 100 g/day rabbit chow containing 0.2% cholesterol for 10 months. Histopathology revealed cupping of the optic disc, atrophy of the retina and hyalinization of the ciliary body in the bilateral eyeballs. These findings corresponded with histopathological features caused by glaucoma. On the basis of these findings, we diagnosed this lesion as glaucoma, and classified it as primary glaucoma because of the presence of developmental defects of the filtration angle. In this case, hypercholesterolemia-induced changes, such as aggregation of lipid-laden macrophages and cholesterin clefts in the sclera or choroid, might cause deterioration of the lesions in glaucoma.
在一只每天喂食含0.2%胆固醇的100克兔粮、持续10个月的新西兰白兔中观察到了前房角发育异常，即滤过角畸形。组织病理学检查显示双侧眼球视盘凹陷、视网膜萎缩和睫状体玻璃样变性。这些发现与青光眼引起的组织病理学特征相符。基于这些发现，我们将此病变诊断为青光眼，并因其存在滤过角发育缺陷而将其归类为原发性青光眼。在这种情况下，高胆固醇血症引起的变化，如巩膜或脉络膜中充满脂质的巨噬细胞聚集和胆固醇裂隙，可能会导致青光眼病变恶化。
