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喷他佐辛与曲吡那敏(“T 药”和“蓝药”)滥用:39 例毒理学发现

Pentazocine and tripelennamine (T's and Blues) abuse: toxicological findings in 39 cases.

作者信息

Poklis A, Mackell M A

出版信息

J Anal Toxicol. 1982 May-Jun;6(3):109-14. doi: 10.1093/jat/6.3.109.

Abstract

The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 and 32, died of stab wounds. Blood concentrations of pentazocine and tripelennamine in these cases ranged from 0.20 to 3.3 mg/L, (mean +/- SD 0.72 +/- 0.64 mg/L) and 0.02 to 1.8 mg/L (mean +/- SD 0.29 +/- 0.40 mg/L), respectively. The six deaths attributed to T's and Blues abuse involved three black males, ages 20, 28 and 49, and three black females, ages 21, 25, and 45 years. Blood concentrations of pentazocine and tripelennamine ranged from 0.44 to 2.5 mg/L and 0.09 to 4.1 mg/L, respectively. Ethanol and diazepam were also detected in 49% and 13% of all deaths, respectively. Foreign body or talc granulomas in lung were the most common pathological finding relevant to the abuse of T's and Blues.

摘要

本文呈现了1979年7月1日至1981年7月30日期间在圣路易斯市因滥用喷他佐辛和曲吡那敏(“T药和蓝药”)而死亡者的尸检结果。33例为凶杀案受害者;其中30例是年龄在21至38岁之间的黑人男性;1例26岁白人男性死于枪伤;2例黑人女性,年龄分别为18岁和32岁,死于刺伤。这些案例中喷他佐辛和曲吡那敏的血药浓度分别为0.20至3.3毫克/升(均值±标准差 0.72±0.64毫克/升)和0.02至1.8毫克/升(均值±标准差 0.29±0.40毫克/升)。因滥用“T药和蓝药”导致的6例死亡涉及3名黑人男性,年龄分别为20岁、28岁和49岁,以及3名黑人女性,年龄分别为21岁、25岁和45岁。喷他佐辛和曲吡那敏的血药浓度分别为0.44至2.5毫克/升和0.09至4.1毫克/升。在所有死亡案例中,分别有49%和13%检测出乙醇和地西泮。肺部异物或滑石肉芽肿是与滥用“T药和蓝药”相关的最常见病理发现。

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