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喷他佐辛与曲吡那敏(“T 药”和“蓝药”)滥用:39 例毒理学发现

Pentazocine and tripelennamine (T's and Blues) abuse: toxicological findings in 39 cases.

作者信息

Poklis A, Mackell M A

出版信息

J Anal Toxicol. 1982 May-Jun;6(3):109-14. doi: 10.1093/jat/6.3.109.

DOI:10.1093/jat/6.3.109
PMID:7109550
Abstract

The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 and 32, died of stab wounds. Blood concentrations of pentazocine and tripelennamine in these cases ranged from 0.20 to 3.3 mg/L, (mean +/- SD 0.72 +/- 0.64 mg/L) and 0.02 to 1.8 mg/L (mean +/- SD 0.29 +/- 0.40 mg/L), respectively. The six deaths attributed to T's and Blues abuse involved three black males, ages 20, 28 and 49, and three black females, ages 21, 25, and 45 years. Blood concentrations of pentazocine and tripelennamine ranged from 0.44 to 2.5 mg/L and 0.09 to 4.1 mg/L, respectively. Ethanol and diazepam were also detected in 49% and 13% of all deaths, respectively. Foreign body or talc granulomas in lung were the most common pathological finding relevant to the abuse of T's and Blues.

摘要

本文呈现了1979年7月1日至1981年7月30日期间在圣路易斯市因滥用喷他佐辛和曲吡那敏(“T药和蓝药”)而死亡者的尸检结果。33例为凶杀案受害者;其中30例是年龄在21至38岁之间的黑人男性;1例26岁白人男性死于枪伤;2例黑人女性,年龄分别为18岁和32岁,死于刺伤。这些案例中喷他佐辛和曲吡那敏的血药浓度分别为0.20至3.3毫克/升(均值±标准差 0.72±0.64毫克/升)和0.02至1.8毫克/升(均值±标准差 0.29±0.40毫克/升)。因滥用“T药和蓝药”导致的6例死亡涉及3名黑人男性,年龄分别为20岁、28岁和49岁,以及3名黑人女性,年龄分别为21岁、25岁和45岁。喷他佐辛和曲吡那敏的血药浓度分别为0.44至2.5毫克/升和0.09至4.1毫克/升。在所有死亡案例中,分别有49%和13%检测出乙醇和地西泮。肺部异物或滑石肉芽肿是与滥用“T药和蓝药”相关的最常见病理发现。

相似文献

1
Pentazocine and tripelennamine (T's and Blues) abuse: toxicological findings in 39 cases.喷他佐辛与曲吡那敏(“T 药”和“蓝药”)滥用:39 例毒理学发现
J Anal Toxicol. 1982 May-Jun;6(3):109-14. doi: 10.1093/jat/6.3.109.
2
Pentazocine/tripelennamine (T's and blues) abuse: a five year survey of St. Louis, Missouri.喷他佐辛/曲吡那敏(“T 与蓝”)滥用:对密苏里州圣路易斯市的五年调查
Drug Alcohol Depend. 1982 Oct-Nov;10(2-3):257-67. doi: 10.1016/0376-8716(82)90020-5.
3
Spontaneous live birth with a maternal history of intravenous use of pentazocine and tripelennamine (T's and blues).
J Forensic Sci. 1983 Apr;28(2):489-95.
4
Determination of pentazocine and tripelennamine in blood of T's and Blue addicts by gas-liquid chromatography with a nitrogen detector.用带氮检测器的气液色谱法测定T氏和Blue氏成瘾者血液中的喷他佐辛和曲吡那敏。
J Chromatogr. 1982 Jan 29;235(2):445-52. doi: 10.1016/s0021-9673(00)85908-7.
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Decline in abuse of pentazocine/tripelennamine (T's and Blues) associated with the addition of naloxone to pentazocine tablets.与在喷他佐辛片剂中添加纳洛酮相关的喷他佐辛/曲吡那敏(“T 片”和“蓝片”)滥用情况的下降。
Drug Alcohol Depend. 1984 Oct;14(2):135-40. doi: 10.1016/0376-8716(84)90039-5.
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Current trends in the abuse of pentazocine and tripelennamine: the metropolitan St. Louis experience.喷他佐辛和曲吡那敏滥用的当前趋势:圣路易斯市区的情况
J Forensic Sci. 1980 Jan;25(1):72-8.
7
Pentazocine (Talwin) and tripelennamine (Pyribenzamine): a new drug abuse combination or just a revival?
Int J Addict. 1980 Nov;15(8):1285-90. doi: 10.3109/10826088009040100.
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T's and blues. Abuse of pentazocine and tripelennamine.丁丙诺啡与三氟拉嗪。喷他佐辛和曲吡那敏的滥用。
JAMA. 1980 Sep 12;244(11):1224-5. doi: 10.1001/jama.244.11.1224.
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Effects of T's and blues abuse on pregnancy outcome and infant health status.吸食冰毒和大麻对妊娠结局及婴儿健康状况的影响。
Am J Perinatol. 1990 Oct;7(4):359-62. doi: 10.1055/s-2007-999523.
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Medical and sociological aspects of T's and Blues abuse in New Orleans.新奥尔良市对摇头丸和蓝调药物滥用的医学与社会学层面
Am J Drug Alcohol Abuse. 1982;9(2):171-82. doi: 10.3109/00952998209002620.

引用本文的文献

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Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. doi: 10.1007/BF00169830.
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First-pass elimination. Basic concepts and clinical consequences.首过消除。基本概念及临床后果。
Clin Pharmacokinet. 1984 Jan-Feb;9(1):1-25. doi: 10.2165/00003088-198409010-00001.
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Potentiation of pentazocine conditioned place preference by tripelennamine in rats.在大鼠中,曲吡那敏增强喷他佐辛条件性位置偏爱
Psychopharmacology (Berl). 1991;105(1):9-12. doi: 10.1007/BF02316857.