Aging of the erythrocyte. XII. Protein composition of the membrane.

The composition of membrane proteins was compared in erythrocyte fractions of different mean age by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and crossed immunoelectrophoresis. An increase in the content of high-molecular-weight protein aggregates with cell aging was confirmed, and enhanced binding of some hemolysate proteins to the membranes in older cells was found.