Pica A J, Brooks G A
Med Sci Sports Exerc. 1982;14(3):249-52.
To study the effects of training and aging on aerobic capacity, 8-wk-old female Wistar rats were assigned to training and sedentary, free-eating control groups (N = 10, each). Training involved 5 wk of daily progressive treadmill running reaching an intensity of 26.8 m . min-1 on 15% grade for 1 h. Training was maintained at this intensity for an additional 11 wk. The VO2max of trained and sedentary control rats was assessed every 2 wk. Peak VO2max (25.4 +/- 3.2 ml . min-1; X +/- SEM) was observed in the trained group at 20 wk of age and represented a 15% increase over the untrained group. When expressed on a relative basis, the peak VO2max in trained rats at 20 wk of age was 86.6 +/- 8.6 ml . kg-1 . min-1, or an 8% improvement compared to controls. In control animals VO2max was also greatest at 20 wk of age (22.0 +/- 1.9 ml . min-1; 79.9 +/- 6.4 ml . kg-1 . min-1). After 20 wk of age, VO2max declined in sedentary controls, but was maintained in trained animals were approximately 6% heavier than sedentary free-eating controls. Endurance training may stimulate anabolic processes as well as improve and maintain aerobic capacity in the female rat.
为研究训练和衰老对有氧能力的影响，将8周龄雌性Wistar大鼠分为训练组和久坐自由进食对照组（每组N = 10）。训练包括连续5周每天进行递增式跑步机跑步，强度达到在15%坡度上以26.8米/分钟的速度跑1小时。在此强度下持续训练11周。每2周评估训练组和久坐对照组大鼠的最大摄氧量（VO2max）。训练组在20周龄时观察到峰值VO2max（25.4±3.2毫升/分钟；X±SEM），比未训练组增加了15%。以相对值表示时，训练大鼠在20周龄时的峰值VO2max为86.6±8.6毫升/千克·分钟，比对照组提高了8%。在对照动物中，VO2max也在20周龄时最大（22.0±1.9毫升/分钟；79.9±6.4毫升/千克·分钟）。20周龄后，久坐对照组的VO2max下降，但训练组的VO2max保持不变，训练组大鼠比久坐自由进食对照组重约6%。耐力训练可能会刺激合成代谢过程，并改善和维持雌性大鼠的有氧能力。
