Darnall R A, Ariagno R L
Pediatr Res. 1982 Jul;16(7):512-4. doi: 10.1203/00006450-198207000-00002.
Alterations in thermoregulatory mechanisms related to sleep state may play an important role in the problems of homeostasis experienced by the premature infant. In the adult, homeothermic regulation of body temperature may be suspended during REM. We measured oxygen consumption (VO2) in six premature infants 33-35 wk gestation both at thermoneutrality and during a mild thermal stress to determine whether thermoregulatory responses were intact during REM sleep. All infants were studied under radiant warmers. Skin temperature was allowed to fall 7-8 times during a 6-8 h study period while VO2, VCO2, heart rate and TcPO2 were continuously recorded. Sleep state was scored using EEG, EOG, EMG and behavioral criteria. A total of 1,162 one-min epochs were scored. In all states including REM, VO2 was significantly higher during the cool periods. The mean increases: 21.5%, 23.3%, 11.1% and 5.3% for Awake, Indeterminate, REM and NREM respectively. When REM and NREM were compared at thermoneutrality, there was no difference in the VO2 (8.80 +/- 0.11 and 8.93 +/- 0.15 cc/kg/min, mean +/- S.E., for REM and NREM, respectively). We conclude that in contrast to the adult, active thermoregulation occurs in the premature infant during REM sleep.
与睡眠状态相关的体温调节机制改变可能在早产儿所经历的体内平衡问题中起重要作用。在成年人中，快速眼动睡眠期间体温的恒温调节可能会暂停。我们测量了6名孕33 - 35周早产儿在中性温度及轻度热应激期间的耗氧量（VO2），以确定快速眼动睡眠期间体温调节反应是否完整。所有婴儿均在辐射保暖箱下进行研究。在6 - 8小时的研究期间，皮肤温度允许下降7 - 8次，同时持续记录VO2、VCO2、心率和经皮氧分压（TcPO2）。使用脑电图、眼电图、肌电图和行为标准对睡眠状态进行评分。共对1162个1分钟时段进行了评分。在包括快速眼动睡眠在内的所有状态下，凉爽时段的VO2均显著更高。平均增加幅度：清醒时为21.5%，不确定状态时为23.3%，快速眼动睡眠时为11.1%，非快速眼动睡眠时为5.3%。在中性温度下比较快速眼动睡眠和非快速眼动睡眠时，VO2没有差异（快速眼动睡眠和非快速眼动睡眠时分别为8.80±0.11和8.93±0.15毫升/千克/分钟，平均值±标准误）。我们得出结论，与成年人不同，早产儿在快速眼动睡眠期间会进行主动体温调节。
