Colpaert F C, Maroli A N, Meert T
Physiol Behav. 1982 Jun;28(6):1047-58. doi: 10.1016/0031-9384(82)90174-3.
Rats were implanted with electrodes in the medial forebrain bundle at the level of the lateral hypothalamus. Electrical stimulation was established as a conditioned stimulus for responding in a modified two-way active shock avoidance procedure. Stimulus generalization experiments were conducted to determine the effects of pulse frequency, current intensity, pulse duration, and of train duration. It was found that the discriminative stimulus properties of the electrical stimulation co-varied in an orderly manner with variations in each of the parameters. The generalization data sets of frequency, intensity, and train duration could be fitted by linear functions in log-linear coordinates; the effects of pulse duration generated a biphasic gradient. An analysis in terms of charge revealed that train duration had the lowest slope, whereas frequency and intensity generated equally steep functions. The most striking differences occurred among conditions which were similar in terms of current intensity, pulse duration and number of pulses, but which differed in the temporal patterning of pulses. Some methodological and analytical aspects of discrimination and generalization with intracranial stimulation are discussed.
大鼠在外侧下丘脑水平的内侧前脑束植入电极。在改良的双向主动回避电击程序中，将电刺激确立为用于反应的条件刺激。进行刺激泛化实验以确定脉冲频率、电流强度、脉冲持续时间和串刺激持续时间的影响。发现电刺激的辨别刺激特性与每个参数的变化呈有序的共变关系。频率、强度和串刺激持续时间的泛化数据集在对数线性坐标中可用线性函数拟合；脉冲持续时间的影响产生双相梯度。基于电荷的分析表明，串刺激持续时间的斜率最低，而频率和强度产生同样陡峭的函数。最显著的差异出现在电流强度、脉冲持续时间和脉冲数量相似，但脉冲时间模式不同的条件之间。讨论了颅内刺激辨别和泛化的一些方法学和分析方面。
