Nilsson C, Rosberg B
Acta Anaesthesiol Scand. 1982 Jun;26(3):240-1. doi: 10.1111/j.1399-6576.1982.tb01762.x.
Fentanyl, though generally regarded as a short-acting narcotic analgesic, can give unexpected respiratory depression several hours after the last dose. This potentially very dangerous effect is explained in pharmacokinetic studies by a mobilisation of fentanyl from tissue stores. In this report we describe a patient who, following a Harrington correction for scoliosis done with neurolept analgesia, developed a severe respiratory depression 5 h after the last dose of fentanyl.
芬太尼虽然通常被视为短效麻醉性镇痛药，但在最后一剂用药数小时后可能会出现意外的呼吸抑制。药代动力学研究表明，这种潜在的非常危险的效应是由于芬太尼从组织储存库中释放出来所致。在本报告中，我们描述了一名患者，该患者在采用神经安定镇痛法进行脊柱侧弯哈林顿矫正术后，于最后一剂芬太尼用药5小时后出现了严重的呼吸抑制。
