Salmi A, Ziola B, Reunanen M, Julkunen I, Wager O
Acta Neurol Scand. 1982 Jul;66(1):1-15. doi: 10.1111/j.1600-0404.1982.tb03124.x.
Paired serum and cerebrospinal fluid (CSF) specimens from 30 multiple sclerosis (MS) patients and 30 patients with other neurological diseases (ONDs) were analyzed for the presence of immune complexes (ICs). With each of the 4 tests used, ICs were found more frequently in sera from both MS and OND patients than in sera from healthy blood donors. IC-positivity for MS and OND patient CSF varied from 10-33% and from 10-17% in different tests. The number of IC-positive sera or CSF in MS patients did not differ significantly from those in OND patients. For both MS and OND patients, the positivity pattern for serum and CSF specimens in each IC test was essentially unique. Furthermore, because several CSF IC-positive and serum IC-negative paired specimens were found, intrathecal IC formation may be independent of IC formation in peripheral blood. The presence of ICs in serum or CSF did not correlate with the clinical status of or laboratory data on the MS patients, nor was a correlation found with the diagnosis of the OND patients. In total, these results suggest that the presence or absence of ICs in MS or OND patients may simply reflect changes in the immunological regulation of individual patients.
对30例多发性硬化症（MS）患者和30例其他神经系统疾病（OND）患者的配对血清和脑脊液（CSF）样本进行分析，以检测免疫复合物（IC）的存在。在所使用的4种检测方法中，MS患者和OND患者血清中IC的检出频率均高于健康献血者血清。MS患者和OND患者脑脊液的IC阳性率在不同检测中分别为10%-33%和10%-17%。MS患者中IC阳性血清或脑脊液的数量与OND患者无显著差异。对于MS患者和OND患者，每种IC检测中血清和脑脊液样本的阳性模式基本是独特的。此外，由于发现了几对脑脊液IC阳性而血清IC阴性的样本，鞘内IC的形成可能独立于外周血中的IC形成。血清或脑脊液中IC的存在与MS患者的临床状态或实验室数据无关，也与OND患者的诊断无关。总体而言，这些结果表明，MS或OND患者中IC的存在与否可能仅仅反映了个体患者免疫调节的变化。
