Gustafsson L L, Boëthius G
Acta Med Scand. 1982;211(6):419-25.
A comparative analysis of the usage of analgesics in the county of Jämtland and in Sweden 1970-78 has been carried out. An attempt was also made to map out the indications for prescribing such drugs. Both in Jämtland and in Sweden as a whole, analgesics sold over the counter accounted for more than half of the total usage. The same was true for fixed drug combinations. Analgesics were prescribed each year to 17% of the population of Jämtland. Fixed drug combinations containing sedatives maintained a large fraction of the amount of analgesics prescribed--31% of defined daily doses (DDDs) in 1978. Arylalkanoic acids (ibuprofen and naproxen), introduced in 1975, soon took a substantial part of the market--13% of DDDs in 1978. Though arylalkanoic acids were registered for treatment of degenerative joint diseases, four of five patients in Jämtland received them only once or twice during a two-year period. In the national study, every third prescription of these drugs was for degenerative joint diseases. The pattern of usage revealed in this study calls for improved pharmacotherapeutic training of physicians to make drug treatment more rational.
对耶姆特兰郡和瑞典1970 - 1978年镇痛药的使用情况进行了比较分析。同时还尝试梳理了此类药物的处方指征。在耶姆特兰郡和整个瑞典，非处方销售的镇痛药占总使用量的一半以上。固定复方制剂也是如此。耶姆特兰郡每年有17%的人口使用镇痛药。含镇静剂的固定复方制剂在镇痛药处方量中占很大比例——1978年占限定日剂量（DDD）的31%。1975年引入的芳基链烷酸（布洛芬和萘普生）很快占据了很大一部分市场——1978年占DDD的13%。尽管芳基链烷酸注册用于治疗退行性关节疾病，但在耶姆特兰郡，五分之四的患者在两年期间仅使用过一两次。在全国性研究中，这些药物每三张处方中就有一张用于治疗退行性关节疾病。本研究揭示的用药模式要求加强对医生的药物治疗培训，以使药物治疗更加合理。
