Heise E, Görlich M
Anticancer Res. 1982 Jan-Apr;2(1-2):33-6.
Disease-free interval and survival time of breast cancer patients were investigated in regard to the estradiol receptor (ER) status as measured in the corresponding primary tumours. Disease-free interval and survival time of patients with ER positive breast cancers were found to be significantly longer than those of patients with ER negative tumours. The percentage of ER positive tumours in patients with finished free interval, or that died as a consequence of their disease, is lower than that found in an unselected material. The ER concentrations did not, however, differ significantly. Patients with ER positive breast cancers of stage IV did not survive longer than patients with ER negative tumours. No correlations could be found between disease-free interval and survival time of the patients, and the ER concentrations measured in their corresponding tumours individually. The menopausal status of the patients influenced the disease free interval regardless the ER status of the primary tumours. The survival time of postmenopausal patients with ER positive breast cancers were found to be significantly longer than that of premenopausal patients with ER negative cancers. The average ER concentration of breast cancers of postmenopausal patients with finished free interval is significantly higher than the valve found in cancers of premenopausal patients.
针对相应原发肿瘤中所检测的雌二醇受体（ER）状态，对乳腺癌患者的无病生存期和生存时间进行了研究。结果发现，ER阳性乳腺癌患者的无病生存期和生存时间显著长于ER阴性肿瘤患者。在完成无病间期或因疾病死亡的患者中，ER阳性肿瘤的百分比低于未经过筛选的病例材料中的比例。然而，ER浓度并无显著差异。IV期ER阳性乳腺癌患者的生存时间并不比ER阴性肿瘤患者更长。在患者的无病生存期和生存时间与各自相应肿瘤中所检测的ER浓度之间未发现相关性。患者的绝经状态影响无病间期，而与原发肿瘤的ER状态无关。已发现绝经后ER阳性乳腺癌患者的生存时间显著长于绝经前ER阴性癌症患者。绝经后完成无病间期的乳腺癌患者的平均ER浓度显著高于绝经前患者癌症中的数值。
