Majeski J A, Morris M J, Alexander J W
J Antibiot (Tokyo). 1978 Oct;31(10):1059-62. doi: 10.7164/antibiotics.31.1059.
Polymorphonuclear neutrophilic leukocyte chemotaxis was examined in vitro in the presence to two new antibiotics: cefamandole and cefoxitin. Results indicate that cefamandole inhibited neutrophil chemotaxis to a significant degree only at high antibiotic concentrations of 100 microgram/ml (P less than 0.01) and has no significant effect at normal serum therapeutic range. Cefoxitin was found to produce a 43% inhibition (P less than 0.01) of human in vivo neutrophil chemotaxis at antibiotic concentrations of 100 microgram/ml and have a minimal inhibitory effect (1 approximately 9%) at low concentrations (1 approximately 5 microgram/ml). Both cefamandole and cefoxitin had no significant effect on opsonophagocytosis.
在两种新型抗生素头孢孟多和头孢西丁存在的情况下，对多形核嗜中性白细胞趋化性进行了体外检测。结果表明，仅在100微克/毫升的高抗生素浓度下，头孢孟多才会对嗜中性白细胞趋化性产生显著抑制（P<0.01），而在正常血清治疗范围内无显著影响。发现头孢西丁在100微克/毫升的抗生素浓度下会对人体体内嗜中性白细胞趋化性产生43%的抑制作用（P<0.01），而在低浓度（1至5微克/毫升）时具有最小抑制作用（1至9%）。头孢孟多和头孢西丁对调理吞噬作用均无显著影响。
