Sharma S K, Dilawari J B, Anand B S
Gastroenterol Jpn. 1982;17(3):187-91. doi: 10.1007/BF02775994.
Pancreatic functions were studied in 15 patients with tropical sprue. The diagnosis of tropical sprue was made on accepted criteria of demonstrating malabsorption of at least two unrelated food substances in the absence of any other cause for malabsorption in patients residing in a tropical zone. Exogenous secretion (Boots) in a dose of one clinical unit per kg was employed for direct stimulation of exocrine pancreatic secretion. Of the 15 patients, 12 showed normal pancreatic functions. In two patients, volume output was marginally low i.e. 1.6 and 1.6 ml/kg/hr respectively (Normal value greater than 1.8 ml/kg/hr). In the third patient, volume output was normal but maximum bicarbonate concentration in pancreatic juice was 61.6 mEq/litre (Normal value greater than 80 mEq/litre). None of these three patients, however, had abnormalities in both the parameters of exocrine pancreatic function. Although pancreatic hyposecretion has been reported in patient with tropical sprue when indirect stimulation with Lundh meal was applied to pancreas, yet on direct stimulation with secretin, we found pancreatic functions to be normal. It is therefore concluded that the pancreas is not primarily involved in tropical sprue.
对15例热带口炎性腹泻患者的胰腺功能进行了研究。热带口炎性腹泻的诊断依据是公认的标准，即在热带地区居住的患者中，在不存在任何其他吸收不良原因的情况下，至少两种不相关食物物质出现吸收不良。采用每千克1个临床单位剂量的外源性促胰液素（Boots）直接刺激胰腺外分泌。15例患者中，12例胰腺功能正常。2例患者的分泌量略低，分别为1.6和1.6毫升/千克/小时（正常值大于1.8毫升/千克/小时）。第3例患者的分泌量正常，但胰液中最大碳酸氢盐浓度为61.6毫当量/升（正常值大于80毫当量/升）。然而，这3例患者中没有1例在外分泌胰腺功能的两个参数上都有异常。虽然在对胰腺应用Lundh餐进行间接刺激时，已报道热带口炎性腹泻患者存在胰腺分泌不足，但在用促胰液素进行直接刺激时，我们发现胰腺功能正常。因此得出结论，胰腺并非热带口炎性腹泻的主要受累器官。
