Wiernikowski A, Piekoszewski W, Krzyzanowska-Kierepka E, Gomułka E
Kliniki Toksykologii Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1997;54(6):459-63.
The symptoms and clinical course of repeated poisonings with isopropyl alcohol in ethanol addicted 43-years old man is presented in the study. The blood and urine concentrations of isopropanol and acetone and also the blood ethanol concentration are given. The biological half-life of isopropanol calculated for the first 12 hours from admission to the Clinic was 6.9 hours. The biological half-life of acetone in the first 6 hours of hospitalisation was 5 hours, and then a considerable slowing down up to 29 hours was noted. The clinical symptoms, similar to ethanol poisoning, including strongly manifested catatonia and ketonuria without metabolic acidosis indicate the isopropanol intoxication. Hypokalemia should to be taken into consideration in treatment of isopropanol poisoning. An intravenous bicarbonates should be administered carefully e.g. when rhabdomyolysis occur.
本研究报告了一名43岁乙醇成瘾男性反复异丙醇中毒的症状及临床病程。文中给出了异丙醇、丙酮的血药浓度和尿药浓度以及血液乙醇浓度。从入院到诊所的前12小时计算得出异丙醇的生物半衰期为6.9小时。住院治疗的前6小时丙酮的生物半衰期为5小时，随后显著延长至29小时。临床症状与乙醇中毒相似，包括明显的紧张症和酮尿症，但无代谢性酸中毒，提示异丙醇中毒。治疗异丙醇中毒时应考虑低钾血症。例如，发生横纹肌溶解时，应谨慎静脉输注碳酸氢盐。
