重度哮喘患者血浆、血液及尿液中的组胺水平以及皮质类固醇治疗的效果。
Histamine levels in plasma, blood, and urine in severe asthma, and the effect of corticosteroid treatment.
作者信息
Bruce C, Weatherstone R, Seaton A, Taylor W H
出版信息
Thorax. 1976 Dec;31(6):724-9. doi: 10.1136/thx.31.6.724.
Abstract
Plasma, whole blood, and urinary histamine levels have been determined in 64 normal subjects, in 10 patients with severe asthma, and in 10 control patients with other illnesses. The mean whole blood levels did not differ between the three groups. The mean plasma level in the asthmatics was significantly greater than that of the normal subjects but not of the control patients. The urinary histamine output was lower in the control patients than in the normal subjects but in the asthmatics did not differ from that of the normals. Corticosteroid therapy caused a marked fall, often to barely detectable levels, of the whole blood histamine concentration of the asthmatic patients and restored the plasma levels to normal but did not affect urinary histamine levels.
摘要
已对64名正常受试者、10名重症哮喘患者和10名患有其他疾病的对照患者测定了血浆、全血和尿液中的组胺水平。三组之间的全血平均水平没有差异。哮喘患者的血浆平均水平显著高于正常受试者，但与对照患者相比无显著差异。对照患者的尿组胺排出量低于正常受试者，但哮喘患者的尿组胺排出量与正常受试者无差异。皮质类固醇治疗使哮喘患者全血组胺浓度显著下降，常常降至几乎检测不到的水平，并使血浆水平恢复正常，但不影响尿组胺水平。
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