Zimmermann I, de Almeida A A, Ulmer W T
Res Exp Med (Berl). 1980;177(2):91-100. doi: 10.1007/BF01851837.
In 19 dogs sensitized against Ascaris suum extract we measured dynamic elastance, arterial plasma histamine concentration, pressure in the A. femoralis, and arterial blood gases. In six dogs the venous plasma histamine concentration was also analyzed. Ascaris extract (A.E.) inhalation increased both the arterial and the venous plasma histamine concentration significantly. The venous concentration was 61% of that detected in the arterial blood. At the same arterial plasma histamine level a large variety of dynamic elastance was measured which shows great individual differences in the sensitivity of the bronchoconstrictive system. This histamine released by the bronchopulmonary system works mostly via reflex bronchoconstriction. There was significant correlation between dynamic elastance and arterial oxygen pressure as well as between arterial plasma histamine concentration and systemic blood pressure.
在19只对猪蛔虫提取物致敏的犬中，我们测量了动态弹性、动脉血浆组胺浓度、股动脉压力和动脉血气。在6只犬中还分析了静脉血浆组胺浓度。吸入猪蛔虫提取物（A.E.）显著增加了动脉和静脉血浆组胺浓度。静脉浓度为动脉血中检测浓度的61%。在相同的动脉血浆组胺水平下，测量到多种动态弹性，这表明支气管收缩系统的敏感性存在很大个体差异。支气管肺系统释放的这种组胺主要通过反射性支气管收缩起作用。动态弹性与动脉血氧分压之间以及动脉血浆组胺浓度与全身血压之间存在显著相关性。
