Zimmermann I, Bugalho de Almeida A A, Ulmer W T
Res Exp Med (Berl). 1980;177(3):181-91. doi: 10.1007/BF01851208.
Inhalation of acetylcholine causes increased histamine concentration in the arterial plasma. This increase is smaller than that following allergen inhalation. The increase in Edyn following ACH inhalation may be related to the histamine released to only a very limited extent. Comparison of the effects of histamine inhalation and allergen inhalation on Edyn and plasma histamine concentration leads to the assumption that sensory receptors are located nearer to the surface of the mucosa than that of the mast cells. Hypoxemia is followed by a slight increase in the arterial plasma histamine concentration. The increase in Edyn corresponds to that caused by allergen inhalation although the increase in Edyn and that in the plasma histamine are much smaller.
吸入乙酰胆碱会导致动脉血浆中组胺浓度升高。这种升高幅度小于吸入变应原后的升高幅度。吸入乙酰胆碱后气道动力的增加可能仅在非常有限的程度上与组胺释放有关。比较吸入组胺和吸入变应原对气道动力和血浆组胺浓度的影响后得出这样的假设：感觉感受器比肥大细胞更靠近黏膜表面。低氧血症后动脉血浆组胺浓度会略有升高。气道动力的增加与吸入变应原引起的增加相当，尽管气道动力的增加和血浆组胺的增加要小得多。
