Bartel L L, Hussey J L, Shrago E
Metabolism. 1982 Sep;31(9):944-7. doi: 10.1016/0026-0495(82)90186-x.
Serum free carnitine, free fatty acid and triglyceride values were followed in patients with end-stage renal disease on maintenance dialysis therapy. During dialysis a decrease in serum carnitine was documented. Whereas the elevated triglyceride concentration remained constant, there was a sharp rise in free fatty acids during the dialysis procedure. This pattern occurred whether patients were subjected to hemodialysis or intermittent peritoneal dialysis. Peritoneal dialysis was performed in a rat model and produced results similar to those observed in human subjects. Furthermore, it could be demonstrated that peritoneal dialysis initiated the hypertriglyceridemia in the otherwise normal animal within a short time period. Whereas the abnormalities observed in carnitine and fatty acid metabolism may or may not be causally related in rat or man, they both seem to result from dialysis therapy.
对接受维持性透析治疗的终末期肾病患者的血清游离肉碱、游离脂肪酸和甘油三酯值进行了跟踪监测。透析过程中记录到血清肉碱减少。虽然甘油三酯浓度升高保持不变，但在透析过程中游离脂肪酸急剧上升。无论患者接受血液透析还是间歇性腹膜透析，都会出现这种情况。在大鼠模型中进行了腹膜透析，其结果与在人类受试者中观察到的结果相似。此外，可以证明腹膜透析在短时间内使原本正常的动物发生高甘油三酯血症。虽然在大鼠或人类中观察到的肉碱和脂肪酸代谢异常可能存在因果关系，也可能不存在，但它们似乎都是由透析治疗引起的。
