Kawai K, Nozawa Y, Ito T, Yamanaka N
Res Commun Chem Pathol Pharmacol. 1982 Jun;36(3):429-38.
Effects of xanthomegnin and duclauxin on mitochondrial respiration, L1210 culture cells of murine leukemia and Ehrlich ascitic tumor were compared. Both compounds exhibited similarly potent uncoupling effects on the oxidative phosphorylation of mitochondria and cyto-toxicities on the culture cells, but they were not equal in the anti-tumor activity on Ehrlich ascitic tumor. Duclauxin markedly increased the life-span of mice which were i.p. inoculated with Ehrlich ascitic tumor but xanthomegnin did not exhibit such effect as duclauxin.
比较了黄天精和杂色曲霉素对线粒体呼吸的影响，以及对小鼠白血病L1210培养细胞和艾氏腹水瘤的作用。两种化合物对线粒体的氧化磷酸化均表现出相似的强效解偶联作用，对培养细胞也具有相似的细胞毒性，但它们对艾氏腹水瘤的抗肿瘤活性并不相同。杂色曲霉素显著延长了腹腔接种艾氏腹水瘤小鼠的寿命，但黄天精并未表现出与杂色曲霉素相同的效果。
