Nielsen S L, Parving H H, Hansen J E
Acta Endocrinol (Copenh). 1982 Sep;101(1):32-4. doi: 10.1530/acta.0.1010032.
Cold hands is a common complaint in myxoedema and were reported by 15 of 17 patients before treatment of myxoedema with 4 having Raynaud's phenomenon. An increased cold sensitivity of the digital arteries could be demonstrated during finger cooling in about half of the patients and Raynaud's phenomenon was verified in the 4 patients as digital arterial closure. The cold sensitivity decreased significantly after treatment with L-thyroxine. The increased cold sensitivity in untreated myxoedema is probably due to an increased sympathetic discharge to the hands that might disclose a predisposition for Raynaud's phenomenon.
手部冰冷是黏液性水肿患者的常见主诉，17例黏液性水肿患者中有15例在接受治疗前报告有此症状，其中4例伴有雷诺现象。在大约一半的患者中，手指冷却时可显示指动脉对冷的敏感性增加，4例患者经证实存在雷诺现象，表现为指动脉闭塞。用左旋甲状腺素治疗后，冷敏感性显著降低。未经治疗的黏液性水肿患者冷敏感性增加可能是由于手部交感神经放电增加，这可能揭示了其患雷诺现象的易感性。
