Holm L E, Lundquist P G, Silfverswärd C, Sobin A
Acta Otolaryngol. 1982 Jul-Aug;94(1-2):185-92. doi: 10.3109/00016488209128904.
A system for histological grading of malignancy was applied to ninety-five squamous cell carcinomas from the anterior 2/3 of the tongue. Three parameters relating to the tumour cell population and three parameters relating to the tumour-host relationship were evaluated. The expected 5-year survival expressed as % survivors was 88% for patients with tumours having total malignancy scores of less than 13 points. 65% for 13-16 and 44% for patients with tumours having scores of more than 16. The prognostic significance for 5-year survival was statistically valid for the three different groups of malignancy scoring. The conventional classification according to mode of differentiation did not give equally good correlations for survival or occurrence of metastases. For the evaluation of the biological behaviour of lingual carcinomas, histological grading of malignancy is a better method.
一种恶性肿瘤组织学分级系统应用于95例来自舌前三分之二的鳞状细胞癌。评估了与肿瘤细胞群体相关的三个参数以及与肿瘤-宿主关系相关的三个参数。总恶性评分为13分以下的肿瘤患者，以存活百分比表示的预期5年生存率为88%；评分为13 - 16分的患者为65%；评分超过16分的患者为44%。三种不同恶性评分组对5年生存率的预后意义在统计学上是有效的。根据分化模式的传统分类在生存率或转移发生率方面没有给出同样好的相关性。对于评估舌癌的生物学行为，恶性肿瘤组织学分级是一种更好的方法。
