Tulusan A H, Hamann M, Prestele H, Ramming I, von Maillot K, Egger H
Arch Gynecol. 1982;231(3):177-84. doi: 10.1007/BF02110116.
Receptor assay results were compared with the ultrastructure of 127 breast cancers (112 primary tumors, six recurrent lesions, nine metastases). Tumors were considered to be receptor positive if the receptor levels were greater than or equal to 15 fmol/mg of soluble tissue protein. Most breast cancer had heterogenous cells with different grades of ultrastructural differentiation. a prevalence of well-differentiated cancer cells and an abundance of intracytoplasmic vacuoles had a significant correlation with a positive estrogen receptor status. The correlation was better than between malignancy grades and receptor content. The type of breast cancer and the menopausal status bore no relation to receptor content. Progesterone receptors were found in well-differentiated tumors of low malignancy.
将受体检测结果与127例乳腺癌（112例原发性肿瘤、6例复发病灶、9例转移灶）的超微结构进行了比较。如果受体水平大于或等于15 fmol/mg可溶性组织蛋白，则肿瘤被认为是受体阳性。大多数乳腺癌具有不同超微结构分化程度的异质性细胞。高分化癌细胞的普遍存在和丰富的胞浆内空泡与雌激素受体阳性状态显著相关。这种相关性优于恶性程度与受体含量之间的相关性。乳腺癌的类型和绝经状态与受体含量无关。在低恶性程度的高分化肿瘤中发现了孕激素受体。
