Inman R D, Jovanovic L, Markenson J A, Longcope C, Dawood M Y, Lockshin M D
Arch Intern Med. 1982 Oct;142(10):1813-5.
Sixteen men with systemic lupus erythematosus (SLE) were examined to assess their genetic and hormonal status. The results of buccal smears in 13 patients examined were normal. Hormonal profiling was done in eight patients receiving no steroid therapy. Four patients had elevated plasma estradiol levels (30, 35, 55, and 103 pg/mL; normal, 12 to 23 pg/mL) and elevated plasma estrone levels (115, 150, 155, and 160 pg/mL; normal, 48 to 100 pg/mL). One patient had a decreased serum testosterone level (134 ng/dL; normal, 300 to 1,000 ng/dL), with an elevated luteinizing hormone (LH) level (4.2 ng/mL; normal, 1.6 to 4.0 ng/mL). One patient had an elevation in both levels of serum follicle-stimulating hormone (17.6 ng/mL; normal, 1 to 5 ng/mL) and LH (10.0 ng/mL). Two patients given infusions of 3H-androstenedione and 14C-testosterone had normal findings from kinetic studies of these hormones. Hyperestrogenemia and hypoandrogenemia observed in some men with SLE suggest that female sex hormones may create an immunologic milieu that facilitates the autoimmune phenomena.
对16名系统性红斑狼疮（SLE）男性患者进行了检查，以评估他们的遗传和激素状况。13名接受检查患者的口腔涂片结果正常。对8名未接受类固醇治疗的患者进行了激素分析。4名患者的血浆雌二醇水平升高（30、35、55和103 pg/mL；正常范围为12至23 pg/mL），血浆雌酮水平升高（115、150、155和160 pg/mL；正常范围为48至100 pg/mL）。1名患者的血清睾酮水平降低（134 ng/dL；正常范围为300至1000 ng/dL），促黄体生成素（LH）水平升高（4.2 ng/mL；正常范围为1.6至4.0 ng/mL）。1名患者的血清促卵泡激素水平（17.6 ng/mL；正常范围为1至5 ng/mL）和LH水平（10.0 ng/mL）均升高。2名接受3H-雄烯二酮和14C-睾酮输注的患者，这些激素的动力学研究结果正常。在一些SLE男性患者中观察到的高雌激素血症和低雄激素血症表明，女性性激素可能会营造一种有利于自身免疫现象的免疫环境。
