Stevens J R
Arch Gen Psychiatry. 1982 Oct;39(10):1131-9. doi: 10.1001/archpsyc.1982.04290100011003.
Histologic sections were made from selected regions of the brains of 25 schizophrenic patients aged 21 to 54 years (mean, 43.5 years) who died during their hospitalization at St Elizabeths Hospital, Washington, DC. These sections were compared with similarly prepared sections from the same brain regions of 28 nonschizophrenic patients of similar age, who were hospitalized and died at the same hospital during the same period, and with sections from 20 age-matched, nonpsychiatric patients who died in a general hospital. Although few differences were apparent in material from schizophrenic and nonpsychiatric cases in sections stained for cellular structures, myelin, or axis cylinders, Holzer's stain for glial fibrils demonstrated increased fibrillary gliosis that affected principally the periventricular structures of the diencephalon, the periaqueductal region of the mesencephalon, or the basal forebrain in three fourths of the brains from schizophrenic subjects. Hypothalamus, midbrain tegmentum, and substantia innominata were most often affected. The nature and distribution of the findings suggest previous or low-grade inflammation. Review of the clinical history and course of each case allows some correlations to be made between clinical signs and histopathologic data.
对25名年龄在21至54岁（平均43.5岁）的精神分裂症患者的大脑选定区域制作了组织学切片，这些患者在华盛顿特区圣伊丽莎白医院住院期间死亡。将这些切片与28名年龄相仿的非精神分裂症患者相同脑区的类似制备切片进行比较，这些非精神分裂症患者在同一时期于同一家医院住院并死亡，还与20名年龄匹配的非精神科患者在综合医院死亡后的切片进行比较。尽管在细胞结构、髓磷脂或轴突染色切片中，精神分裂症患者和非精神科患者的材料中几乎没有明显差异，但福尔泽胶质原纤维染色显示，四分之三的精神分裂症患者大脑中，纤维性胶质增生增加，主要影响间脑的脑室周围结构、中脑导水管周围区域或基底前脑。下丘脑、中脑被盖和无名质最常受到影响。这些发现的性质和分布提示既往存在或低度炎症。回顾每个病例的临床病史和病程，可在临床体征和组织病理学数据之间建立一些关联。
