Bogerts B, Falkai P, Haupts M, Greve B, Ernst S, Tapernon-Franz U, Heinzmann U
Department of Psychiatry, University of Düsseldorf, FRG.
Schizophr Res. 1990 Oct-Dec;3(5-6):295-301. doi: 10.1016/0920-9964(90)90013-w.
Volumes of the hippocampal formation, external and internal pallidum, caudate, putamen, and nucleus accumbens were measured in both hemispheres of recently collected post-mortem brains of 18 chronically ill schizophrenics and 21 control subjects. In the schizophrenic group, the hippocampal formation and the internal pallidum were significantly smaller in the right and left hemisphere, whereas external pallidum, putamen, caudate and accumbens were not significantly changed. Volumes of the hippocampus and of all evaluated parts of the basal ganglia were in the male schizophrenics more reduced than in the female patients. The right and left hemispheres were equally affected in both sexes. Since the mean brain weight was in patients and controls nearly identical, the volume differences can not be explained by a general brain atrophy or hypoplasia but rather indicate a more focal lack of brain tissue, by which some clinical features of the disease might be explained.
在18名慢性精神分裂症患者和21名对照者近期采集的死后大脑中，对海马结构、苍白球外部和内部、尾状核、壳核以及伏隔核的体积在两个半球进行了测量。在精神分裂症组中，海马结构和苍白球内部在左右半球均显著较小，而苍白球外部、壳核、尾状核和伏隔核无显著变化。男性精神分裂症患者海马体和基底神经节所有评估部位的体积比女性患者减少得更多。男女两性的左右半球受影响程度相同。由于患者和对照者的平均脑重几乎相同，体积差异不能用一般性脑萎缩或发育不全来解释，而更表明是脑组织的局部缺乏，这或许可以解释该疾病的一些临床特征。
