Shettigar U R, Mann H, Gressner A
Artif Organs. 1982 May;6(2):163-8. doi: 10.1111/j.1525-1594.1982.tb04078.x.
This in vitro study deals with the problem of continuous separation of albumin from globulins in patient's plasma and reinfusion of the useful components of the plasma to the patient as the substitution fluid during a plasma exchange (PE) treatment. A cascade filtration system is developed to generate continuously two plasma fractions, one rich in globulins and the other rich in albumins, using two filters (H1P100 filter with a molecular weight cutoff 100,000 and Diafilter 20 with a molecular weight cutoff 30,000). For example, the system is able to increase the albumin/globulin ratio of plasma from 0.42 to 1.98, and the albumin concentration in the secondary plasma fraction is about seven times higher than that in the primary plasma fraction. This system is expected to be clinically useful in eliminating the side effects inherent in the usage of any other substitution fluid during a PE treatment.
这项体外研究探讨了在血浆置换（PE）治疗过程中，从患者血浆中持续分离白蛋白和球蛋白，并将血浆中的有用成分作为置换液回输到患者体内的问题。开发了一种级联过滤系统，使用两个过滤器（截留分子量为100,000的H1P100过滤器和截留分子量为30,000的Diafilter 20）连续生成两种血浆成分，一种富含球蛋白，另一种富含白蛋白。例如，该系统能够将血浆的白蛋白/球蛋白比值从0.42提高到1.98，二级血浆成分中的白蛋白浓度比一级血浆成分中的白蛋白浓度高约7倍。预计该系统在消除PE治疗期间使用任何其他置换液所固有的副作用方面具有临床实用性。
