局部抗菌剂的耐药性研究。
Drug resistance studies with topical antiseptics.
作者信息
Prince H N, Nonemaker W S, Norgard R C, Prince D L
出版信息
J Pharm Sci. 1978 Nov;67(11):1629-31. doi: 10.1002/jps.2600671134.
PMID:712607
Abstract
Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to povidone-iodine was not encountered. Chlorhexidine resistance was stable after drug-free transfers of Serratia and Pseudomonas but was transitory for Proteus.
摘要
变形杆菌属、沙雷氏菌属和假单胞菌属的菌株在体外传代五至八次后对氯己定产生了耐药性。还检测到对苯扎氯铵的交叉耐药性。未发现对聚维酮碘的耐药性。沙雷氏菌属和假单胞菌属在无药传代后氯己定耐药性稳定，但变形杆菌属的耐药性是暂时的。
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