Mishkin M, Lewis M E, Ungerleider L G
Behav Brain Res. 1982 Sep;6(1):41-55. doi: 10.1016/0166-4328(82)90080-8.
Parieto-preoccipital lesions in monkeys produce a variety of behavioral deficits, many of which can be classified as either visuospatial or tactual. Since the lesions typically invade a number of cytoarchitectonic areas, the diverse behavioral effects could be a consequence of damage of different functional systems. To determine whether visuospatial ability depends critically on particular parieto-preoccipital -- or on a particular combination of them, monkeys with lesions of one, two, or all three of these sectors were tested both on the "landmark' task, a visual distance discrimination, and, for comparison, on a visual pattern discrimination. Impairment was found only on the landmark task, and the severity of the impairment depended on the number of sectors included in the removal, completely independent of their locus. In an attempt to integrate these results with current neurobiological data, we propose that the parieto-preoccipital region consists of two subdivisions that are organized hierarchically for the mediation of spatial perception. The lower-order subdivision, composed largely of the modality-specific preoccipital area, dorsal OA, is postulated to serve visuospatial processes selectively. The higher-order subdivision, composed mainly of the poly-sensory parietal area, PG, is postulated to serve a supramodal spatial ability to which both the visual and tactual modalities contribute.
猴子顶枕叶病变会导致多种行为缺陷，其中许多可归类为视觉空间或触觉方面的缺陷。由于这些病变通常会侵袭多个细胞构筑区，所以多样的行为效应可能是不同功能系统受损的结果。为了确定视觉空间能力是否关键取决于特定的顶枕叶区域——或者它们的特定组合，对这些区域中一个、两个或全部三个区域有损伤的猴子进行了“地标”任务测试，这是一种视觉距离辨别测试，作为比较，还进行了视觉模式辨别测试。结果发现仅在“地标”任务中出现损伤，且损伤的严重程度取决于切除的区域数量，与这些区域的位置完全无关。为了将这些结果与当前的神经生物学数据相结合，我们提出顶枕叶区域由两个细分区域组成，它们为空间感知的介导进行分层组织。较低层级的细分区域主要由特定模态的枕前区、背侧视区OA组成，推测其选择性地服务于视觉空间过程。较高层级的细分区域主要由多感觉顶叶区域PG组成，推测其服务于一种超模态空间能力，视觉和触觉模态都对其有贡献。
