Ivanov V V, Alyshanskiĭ A M
Biull Eksp Biol Med. 1982 Jul;94(7):40-3.
A study was made of the content of biogenic amines as of a number of functions of the plasma membrane of hepatocytes and activity of lipid peroxidation during acute acrylonitrile poisoning. This industrial monomer stimulated all the parts of the sympatho-adrenal system and caused a reduction of the GABA level that is likely to be a consequence of inhibition of glutamate decarboxylase biosynthesis. Moreover, it was found that barrier and regulatory functions of the hepatocyte membrane were impaired. Accumulation of diene conjugates and protective action of alpha-tocopherol that prevented the development of the discovered stressor alterations point to a possible pathogenetic relationship between the disorders seen and poison-induced lipid peroxidation.
对急性丙烯腈中毒期间生物胺含量、肝细胞质膜的一些功能以及脂质过氧化活性进行了研究。这种工业单体刺激了交感 - 肾上腺系统的所有部分，并导致γ-氨基丁酸水平降低，这可能是谷氨酸脱羧酶生物合成受到抑制的结果。此外，还发现肝细胞膜的屏障和调节功能受损。二烯共轭物的积累以及α-生育酚的保护作用阻止了所发现的应激源改变的发展，这表明所见病症与毒物诱导的脂质过氧化之间可能存在致病关系。
