Zemlianskaia T A, Vissarionova V Ia, Bondarev G I
Vopr Pitan. 1979 Jul-Aug(4):56-62.
The effect of ascorbic acid and a mixture of pyridoxine and nicotinamide on the process of subacute poisoning with acrylonitrile (AN) in a concentration of 9.7 +/- 2.8 mg/m3 (corresponding to the threshold of a chronic action) was studied in rats. Administration of an additional mixture of vitamins had no significant effect on the course of subacute poisoning in rats. Changes in the physiological and biochemical parameters characteristic of the AN poisoning were noted in this group of animals at the end of the experiment. No significant changes were observed in the poisoning of rats after an additional administration of ascorbic acid either at the stage of the initial reactions, or at the end of the experiment. The results obtained indicate a strongly pronounced elevation of the adaptibility of the organism. This allows one to regard ascorbic acid as an alimentary factor of protective action in repeated subacute AN poisoning of the organism. Ascorbic acid can be recommended as a prophylactic agent for persons in continuous contact with AN under industrial conditions.
研究了抗坏血酸以及吡哆醇和烟酰胺混合物对大鼠亚急性丙烯腈（AN）中毒过程的影响，丙烯腈浓度为9.7±2.8毫克/立方米（相当于慢性作用阈值）。额外给予维生素混合物对大鼠亚急性中毒进程无显著影响。在该组动物实验结束时，观察到了AN中毒特有的生理和生化参数变化。在初始反应阶段或实验结束时，额外给予抗坏血酸后，大鼠中毒情况未观察到显著变化。所获结果表明机体适应性显著提高。这使得抗坏血酸可被视为机体反复亚急性AN中毒时具有保护作用的营养因素。抗坏血酸可推荐作为工业条件下持续接触AN人员的预防剂。
