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[丙烯腈暴露时治疗性-预防性营养的实验评估]

[Experimental evaluation of therapeutic-prophylactic nutrition in exposure to acrylonitrile].

作者信息

Bondarev G I, Stasenkova K P

出版信息

Vopr Pitan. 1977(5):78-82.

PMID:930043
Abstract

The purpose of the work was to study the prophylactic effect of a synthetic complete ration with an addition of L-cysteine in doses of 300 and 150 mg/kg and also investigation of the protective action exerted by 3 rations with varying content of protein (10, 18 and 30 per cent) and calorific value with a repeated and chronic inhalation of AAN in concentrations of 20 +/- 5 and 9 +/- 2.8 mg/m3. The effectiveness of the food rations under study was evaluated basically according to metabolic criteria. The metabolic indices were found to be the most sensitive ones and changing early following the effect of AAN. For this reason they may serve as criteria for not only assessing the noxious action of the poison, but also in devising the type of the medico-prophylactic dietary.

摘要

这项工作的目的是研究添加剂量为300和150毫克/千克的L-半胱氨酸的合成全价日粮的预防效果,以及研究三种蛋白质含量(10%、18%和30%)和热值不同的日粮在反复和长期吸入浓度为20±5和9±2.8毫克/立方米的丙烯腈时所发挥的保护作用。所研究的食物日粮的有效性主要根据代谢标准进行评估。发现代谢指标是最敏感的指标,在丙烯腈的作用后早期就会发生变化。因此,它们不仅可以作为评估毒物有害作用的标准,还可以用于设计医疗预防饮食的类型。

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