Zisapel N, Egozi Y, Laudon M
Brain Res. 1982 Aug 19;246(1):161-3. doi: 10.1016/0006-8993(82)90157-3.
Dopamine release evoked by electrical field stimulation of slices from various regions of rat brain was assessed in the presence of 10-10-10-5 M melatonin. Inhibition of dopamine release by melatonin was observed in the ventral hippocampus, medulla pons, preoptic area and median and posterior hypothalamus. No inhibitory effect of melatonin on dopamine release was observed in the cerebral cortex, cerebellum, dorsal hippocampus and striatum. Equal concentrations of melatonin were needed to produce half-maximal inhibition in all the regions affected. The results indicate that the brain sites for inhibitory effect of melatonin on dopamine neurosecretion overlap the sites reportedly involved in its modulation of neuroendocrine functions.
在存在10⁻¹⁰ - 10⁻⁵ M褪黑素的情况下，评估了电场刺激大鼠脑不同区域切片所诱发的多巴胺释放。在腹侧海马体、脑桥延髓、视前区以及下丘脑中部和后部观察到褪黑素对多巴胺释放的抑制作用。在大脑皮层、小脑、背侧海马体和纹状体中未观察到褪黑素对多巴胺释放的抑制作用。在所有受影响的区域，产生半数最大抑制所需的褪黑素浓度相同。结果表明，褪黑素对多巴胺神经分泌产生抑制作用的脑区与据报道参与其对神经内分泌功能调节的脑区重叠。
