Kozuka S, Tsubone N, Yasui A, Hachisuka K
Cancer. 1982 Nov 15;50(10):2226-34. doi: 10.1002/1097-0142(19821115)50:10<2226::aid-cncr2820501043>3.0.co;2-3.
In order to clarify the relation of adenoma to carcinoma in the gallbladder, histopathologic examination was made on surgical specimens of 1605 cholecystectomies. Among them, 11 benign adenomas, seven adenomas with malignant change, and 79 invasive carcinomas were found. All of the benign adenomas were 12 mm or less in diameter (average diameter, 5.5 +/- 3.1 mm), while the adenomas having cancerous foci were 12 mm or more in diameter (average diameter, 17.6 +/- 4.4 mm). Most invasive carcinomas were more than 30 mm in diameter. The average patient age was 50.5 +/- 16.3 years for benign adenomas, 58.3 +/- 12.6 years for adenomas with malignant change, and 64.8 +/- 9.6 years for invasive carcinomas. Transition of benign adenoma into carcinoma was histologically traceable. Adenomatous residue was found in 15 (19.0%) of 79 cases of invasive carcinoma.
为了阐明胆囊腺瘤与癌之间的关系，对1605例胆囊切除术的手术标本进行了组织病理学检查。其中，发现11例良性腺瘤、7例伴有恶变的腺瘤和79例浸润性癌。所有良性腺瘤直径均在12mm或以下（平均直径5.5±3.1mm），而有癌灶的腺瘤直径在12mm或以上（平均直径17.6±4.4mm）。大多数浸润性癌直径超过30mm。良性腺瘤患者的平均年龄为50.5±16.3岁，伴有恶变的腺瘤患者为58.3±12.6岁，浸润性癌患者为64.8±9.6岁。良性腺瘤向癌的转变在组织学上是可追溯的。79例浸润性癌中有15例（19.0%）发现腺瘤残留。
