溃疡性结肠炎中的抗结肠抗体和嗜淋巴细胞抗体。
Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.
作者信息
Hibi T, Aiso S, Yoshida T, Watanabe M, Asakura H, Tsuru S, Tsuchiya M
出版信息
Clin Exp Immunol. 1982 Jul;49(1):75-80.
Abstract
The presence of anti-colon antibody in the sera from patients with ulcerative colitis was demonstrated by antibody-dependent cell-mediated cytotoxicity (ADCC) assay. In addition, the high prevalence of lymphocytophilic antibody in the sera from patients with ulcerative colitis was obtained by fluorescence activated cell sorter (FACS) analysis. This lymphocytophilic antibody was absorbed by rat colon epithelial cells. Moreover the lymphocytes from ulcerative colitis showed lower binding capacity to this antibody, but acquired higher binding capacity after 20 hr incubation at 37 degrees C in vitro. These data suggest that ADCC may have some role in the pathogenesis of ulcerative colitis.
摘要
通过抗体依赖的细胞介导的细胞毒性（ADCC）测定证实了溃疡性结肠炎患者血清中存在抗结肠抗体。此外，通过荧光激活细胞分选仪（FACS）分析发现溃疡性结肠炎患者血清中嗜淋巴细胞抗体的高患病率。这种嗜淋巴细胞抗体被大鼠结肠上皮细胞吸收。此外，溃疡性结肠炎患者的淋巴细胞对该抗体的结合能力较低，但在37℃体外孵育20小时后获得了较高的结合能力。这些数据表明ADCC可能在溃疡性结肠炎的发病机制中起一定作用。
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