Cracchiolo A, Revell P
Clin Orthop Relat Res. 1982 Oct(170):169-74.
Significant levels of the major components of metal prostheses in total knee arthroplasty were measured in the synovial fluids from patients with these implants. Cobalt (Co), Chromium (Cr), and Nickel (Ni) concentrations were determined by atomic absorption spectrophotometry on 26 synovial fluid samples from 18 patients with hinged (metal-on-metal) prostheses and eight patients with nonhinged (metal-on-polyethylene) prostheses. Concentrations of Co, Cr, and Ni were significantly higher in synovial fluids from hinged knees, as were Ni concentrations in fluids from nonhinged knees. Of the three metals, Ni showed some evidence of increases solubility. The metal debris did not appear to provoke a leukocyte response, insofar as surprisingly low numbers of neutrophils were present in these fluids, all of which were obtained from nonseptic knees. However, significant numbers of lymphocytes and large mononuclear cells were present in the fluids.
在接受全膝关节置换术的患者的滑液中，检测到了金属假体主要成分的显著含量。通过原子吸收分光光度法，对18例使用铰链式（金属对金属）假体和8例使用非铰链式（金属对聚乙烯）假体的患者的26份滑液样本进行了钴（Co）、铬（Cr）和镍（Ni）浓度的测定。铰链式膝关节滑液中的钴、铬和镍浓度显著高于非铰链式膝关节滑液，非铰链式膝关节滑液中的镍浓度也显著升高。在这三种金属中，镍显示出一定的溶解度增加的迹象。金属碎屑似乎并未引发白细胞反应，因为这些滑液中中性粒细胞数量出奇地少，且所有样本均取自无菌膝关节。然而，这些滑液中存在大量淋巴细胞和大单核细胞。
