Levin R M, Jason C, Black S, Nickolai D, Potter D, Grossman M
Clin Pediatr (Phila). 1982 Nov;21(11):693-5. doi: 10.1177/000992288202101110.
The child presented in this report received intravenous amphotericin B 0.5 mg/kg every 36 hours, for dialysis-associated Candida peritonitis. Just prior to her third dose of amphotericin B, the peritoneal fluid concentration of this drug was 0.1 mcg/ml, and the simultaneous serum level was 0.2 mcg/ml. An hour following the third amphotericin B dose, the peritoneal fluid and serum concentrations were 0.2 and 0.4 mcg/ml respectively. The minimal inhibitory concentration (MIC) of amphotericin B for the C. albicans isolated from this patient was 0.05 mcg/ml, and the minimal lethal concentration (MLC) was 0.1 mcg/ml. Treatment included concurrent 5-fluorocytosine, and catheter removal. This is the first time that measurements of concentrations of amphotericin B in the peritoneal fluid have been reported in a child with peritonitis.
本报告中所述患儿因透析相关性念珠菌性腹膜炎接受静脉注射两性霉素B，剂量为每36小时0.5mg/kg。就在她第三次注射两性霉素B之前，该药物的腹膜液浓度为0.1mcg/ml，同时血清水平为0.2mcg/ml。第三次注射两性霉素B一小时后，腹膜液和血清浓度分别为0.2mcg/ml和0.4mcg/ml。从该患者分离出的白色念珠菌对两性霉素B的最低抑菌浓度（MIC）为0.05mcg/ml，最低致死浓度（MLC）为0.1mcg/ml。治疗包括同时使用5-氟胞嘧啶，并拔除导管。这是首次报道在一名患有腹膜炎的儿童中测量腹膜液中两性霉素B的浓度。
