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甲状腺功能亢进症中的糖化血红蛋白水平。

Hemoglobin Ai levels in hyperthyroidism.

作者信息

Saito T, Sato T, Yamamoto M, Kokubun M, Ito M, Inoue M, Saito K, Hoshi H, Saito S, Yoshinaga K

出版信息

Endocrinol Jpn. 1982 Apr;29(2):137-40. doi: 10.1507/endocrj1954.29.137.

Abstract

Hemoglobin AI (HbAI) was studied in 21 cases of hyperthyroidism (H) and 33 control subjects (C). The correlation equations between fasting blood glucose (FBG, mg/dl, x) and HbAI (%, y) in the H and C groups were: y=0.07x+1.26 (r=0.5, p less than 0.05) and y=0.048x+2.23 (r=0.94, p less than p.001), respectively. Five cases in the H group showed a higher level of HbAI far outside the confidence of 5% level of significance calculated from correlation equation for the C group. The correlation equation for the sum of blood glucose (sigma BG, mg/dl, x) during GTT and HbAI (%, y) in the H group was y=0.003x+5.3 (r=0.64, p less than 0.01); in the C group y=0.005x+3.1 (r=0.88, p less than 0.001). sigma BG and HbAI showed a close correlation in both groups. According to the results of the GTT, the subjects, either C or H group, were divided into three sub-groups: normal (n), borderline (b) and diabetic (d). The correlation equation between triiodothyronine (T3, ng/dl, x) and HbAI (%, y) in the H group was calculated as y=0.003x+6.49 (r=0.58, p less than 0.05). T3 in the n subgroup was 331 +/- 90 ng/dl, in the b subgroup 362+/-166 ng/dl and in the d subgroup 621+/-227 ng/dl, and there was a statistical difference between the b and d groups.

摘要

对21例甲状腺功能亢进症(H)患者和33例对照者(C)进行了糖化血红蛋白AI(HbAI)研究。H组和C组空腹血糖(FBG,mg/dl,x)与HbAI(%,y)的相关方程分别为:y = 0.07x + 1.26(r = 0.5,p<0.05)和y = 0.048x + 2.23(r = 0.94,p<0.001)。H组中有5例患者的HbAI水平明显高于根据C组相关方程计算出的5%显著性水平的置信区间。H组葡萄糖耐量试验(GTT)期间血糖总和(σBG,mg/dl,x)与HbAI(%,y)的相关方程为y = 0.003x + 5.3(r = 0.64,p<0.01);C组为y = 0.005x + 3.1(r = 0.88,p<0.001)。两组中σBG与HbAI均显示出密切相关性。根据GTT结果,C组和H组的受试者均被分为三个亚组:正常(n)、临界(b)和糖尿病(d)。计算出H组三碘甲状腺原氨酸(T3,ng/dl,x)与HbAI(%,y)的相关方程为y = 0.003x + 6.49(r = 0.58,p<0.05)。n亚组的T3为331±90 ng/dl,b亚组为362±166 ng/dl,d亚组为621±227 ng/dl,b组和d组之间存在统计学差异。

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