Tötterman S
Eur J Radiol. 1982 Aug;2(3):242-5.
Theophylline (TH), which has been shown in experimental dogs to increase bile-salt-independent bile flow, was studied in its effect on the biliary excretion and concentration of the intravenous contrast medium ioglycamide in cholecystectomized anesthetized dogs equipped with a Thomas cannula through which the common bile duct could be cannulated. One hour after cannulation, i.v. infusion of ioglycamide at the rate of 4 mol/min/Kg was started. Two hours later, 10 mg/kg of TH was injected intravenously and the experiment continued for a further 75 minutes. Bile was collected at 15 min. intervals throughout the whole experiment and simultaneous intravenous blood samples were taken. In this study, TH increased bile flow and decreased biliary ioglycamide concentration. Although TH increased bile flow, it had no effect on the biliary excretion of ioglycamide. It may be postulated that the organic anion ioglycamide, and possibly other organic anions, are secreted into the bile by mechanisms, unaffected by drugs which increase bile-salt-independent bile flow in a similar manner to TH.
在实验犬中已证明茶碱（TH）可增加不依赖胆盐的胆汁流量，本研究观察了其对胆囊切除且麻醉的犬胆汁排泄及静脉造影剂碘甘脲浓度的影响，这些犬配备有托马斯套管，通过该套管可对胆总管进行插管。插管1小时后，开始以4摩尔/分钟/千克的速率静脉输注碘甘脲。两小时后，静脉注射10毫克/千克的TH，并将实验再持续75分钟。在整个实验过程中每隔15分钟收集胆汁，并同时采集静脉血样。在本研究中，TH增加了胆汁流量并降低了胆汁中碘甘脲的浓度。虽然TH增加了胆汁流量，但对碘甘脲的胆汁排泄没有影响。可以推测，有机阴离子碘甘脲以及可能的其他有机阴离子，是以不受药物影响的机制分泌到胆汁中的，这些药物以与TH类似的方式增加不依赖胆盐的胆汁流量。
