Geĭtman I Ia, Kardash B E, Kivman G Ia
Farmakol Toksikol. 1982 Jul-Aug;45(4):83-5.
The kinetics of free sulfalene in the blood and cerebrospinal fluid was studied in patients suffering from chronic arachnoiditis without marked inflammation signs on the part of arachnoid after a single intake of 2 g of the drug. It was found that administration of the drug in this dose once a week is quite justified and that sulfalene penetrates well in the cerebrospinal fluid. Upon administering large doses of the drug its absorption from the gastrointestinal tract declines. Sulfalene is eliminated from the cerebrospinal fluid more slowly than from the blood. High enough drug concentration is maintained in the cerebrospinal fluid for 7 days.
在患有慢性蛛网膜炎且蛛网膜无明显炎症迹象的患者中，研究了单次服用2克药物后血液和脑脊液中游离舒法仑的动力学。结果发现，每周一次给予该剂量的药物是完全合理的，并且舒法仑能很好地渗透到脑脊液中。给予大剂量药物时，其从胃肠道的吸收会下降。舒法仑从脑脊液中的消除比从血液中更慢。脑脊液中能维持足够高的药物浓度达7天。
